The purpose of this workshop is to introduce statisticians to the problems in the new bioinformatics area of metabolomics and to introduce biochemists to new, useful statistical tools.
Metabolomics is similar in its aims to proteomics and micro arrays - the goals include providing disease markers and identifying drug efficacy and explaining side effects. In metabolomics there about 900 metabolites (unlike proteomics, with 250,00 proteins, or micro arrays, with 20,000 genes). Additionally we know metabolic pathways, the stochiometry, and the rates of biochemical reactions for most of the key metabolic processes. This detailed domain knowledge give metabolomics some significant advantages of the other -omic sciences.
The workshop will be held at NISS from 1:00 to 5:00 PM on Thursday, July 15, and from 8:30 AM to 4:30 PM on Friday, July 15. Thursday afternoon will be devoted to basic lectures on assay methods, biochemistry and three statistical software systems. Friday will examine metabolomics from a biochemical and mathematical prospective.
Program and Presentations
1. An overview of Metabolomics - Chris Beecher, Metabolon
2. Biomedical applications of metabolomics technologies - Christopher Newgard, Duke
3. Analyzing Metabolomic datasets- Jack Liu, GSK
4. Exploring metabolomic data with recursive partitioning - Susan Simmons, UNC-Wilmington
Wine and cheese reception at Metabolon (800-1 Capitola Drive in RTP)
Friday July 15
Location: Radisson Research Triangle Park
08:15 Continental Breakfast
09:00 Stan Young, NISS, Workshop Introduction
09:15 Herbert Thiele, Bruker Daltonics, Multivariate data analysis for metabolomics data generated by NMR / MS spectroscopy
10:10 Break
10: 25 John Weinstein, NCI, Integromic analysis of diverse molecular databases
11:20 Douglas Hawkins, Univ. of Minnesota, Tackling Lack of Determination
12:15 - 1:15 Lunch
1:15 Bruce Kristal , Cornell, The Metabolic Serotype of Dietary Restriction: Markers for Disease Risk in Humans?
2:00 Kwan Lee, GSK, Integrative Analysis of High Dimensional Gene Expression, Metabolite and Protein Data
2:45 Break
3:00 Evgeni Selkov, Argonne National Laboratory, Reconstructing metabolic networks, predicting their regulatory mechanisms and dynamics from sequenced genomes, metabolomics, and mathematical simulation
3:45 Panel discussion, Alan Menius, GSK
David Balshaw, NIEHS
Terry Walker, GSK
John Weinstein, NCI
4:30 Adjourn